2020
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C. VALET, A. BATUT, A. VAUCLARD, A. DORTIGNAC, M. BELIO, B. PAYRASTRE, P. VALET & S. SEVERIN. Adipocyte fatty acid transfer supports megakaryocyte maturation. Cell Rep.
E. CLEMENT, I. LAZAR, C. ATTANÉ, L. CARRIÉ, S. DAUVILLIER, M. DUCOUX-PETIT, T. MENNETEAU, M. MOUTAHIR, S. LE GONIDEC, S. DALLE, P. VALET, O. BURLET-SCHILTZ, C. MULLER & L. NIETO. Adipocyte vesicles: 'all-in-one' packages that stimulate tumor mitochondrial metabolism and dynamics. EMBO J.
F. GUERVILLE, P. DE SOUTO BARRETO, I. ADER, S. ANDRIEU, L. CASTEILLA, C. DRAY, N. FAZILLEAU, S. GUYONNET, D. LANGIN, R. LIBLAU, A. PARINI, P. VALET, N. VERGNOLLE, Y. ROLLAND & B. VELLAS. Revisiting the hallmarks of aging to identify markers of biological age. Journal of Prevention of Alzheimers Disease
C. ATTANE, D. ESTEVE, K. CHAOUI, J. IACOVONI, J. CORR, M. MOUTAHIR, P. VALET, O. SCHILTZ, N. REINA & C. MULLER. Yellow adipocyte from human bone marrow exhibit specific lipid metabolism compared to classical white adipocytes. Cell Rep.
Y. SANTIN, S. LOPEZ, I. ADER, S. ANDRIEU, N. BLANCHARD, A. CARRIÈRE, L. CASTEILLA, B. COUSIN, N. DAVEZAC, P. DE SOUTO BARRETO, C. DRAY, N. FAZILLEAU, D. GONZALEZ-DUNIA, P. GOURDY, S. GUYONNET, N. JABRANE-FERRAT, O. KUNDUZOVA, F. LEZOUALC'H, R. LIBLAU, L. MARTINEZ, C. MORO, P. PAYOUX, L. PÉNICAUD, V. PLANAT-BÉNARD, C. RAMPON, Y. ROLLAND, J. SCHANSTRA, F. SIERRA, P. VALET, A. VARIN, N. VERGNOLLE, B. VELLAS, J. VIÑA, B. GUIARD & A. PARINI. Towards a large-scale assessment of relationship between biological and chronological aging: The INSPIRE Mouse Cohort. The Journal of Frailty & Aging.
I. CASTAN-LAURELL, R. EL BOUSTANY, O. PEREIRA, L. POTIER, M. MARRE, F. FUMERON, P. VALET, P. GOURDY, G. VELHO & R. ROUSSEL. Plasma apelin and risk of type 2 diabetes in a cohort from the community. Diabetes Care 43 : e15-e16, 2020.
P. BARRETO, S. GUYONNET, I. ADER, S. ANDRIEU, L. CASTEILLA, N. DAVEZAC, C. DRAY, N. FAZILLEAU, P. GOURDY, R. LIBLAU, A. PARINI, P. PAYOUX, L. PÉNICAUD, C. RAMPON, Y. ROLLAND, P. VALET, N. VERGNOLLE & B. VELLAS. The INSPIRE research initiative: a program for GeroScience and healthy aging research going from animal models to humans and the healthcare system. J. Frailty Ageing.
V. JARGAUD, S. BOUR, F. TERCE, X. COLLET, P. VALET, A. BOULOUMIE, J-C. GUILLEMOT, P. MAURIEGE, S. JALKANEN, C. STOLEN, M. SALMI, D. SMITH & C. CARPENE. Obesity of mice lacking VAP-1/SSAO by Aoc3 gene deletion is reproduced in mice expressing a mutated vascular adhesion protein-1 (VAP-1) devoid of amine oxidase activity. J. Physiol. Biochem.
S. GUYONNET, Y. ROLLAND, P. DE SOUTO BARRETO, C. TAKEDA, I. ADER, L. CASTEILLA, N. DAVEZAC, C. DRAY, N. FAZILLEAU, P. GOURDY, R. LIBLAU, A. PARINI, P. PAYOUX, L. PÉNICAUD, C. RAMPON, P. VALET, N. VERGNOLLE, S. ANDRIEU & B. VELLAS. The INSPIRE Bio-resource Research Platform for Healthy Aging and Geroscience: Focus on the Human Translational Research Cohort (The INSPIRE-T Cohort). J. Frailty Ageing.
R. PACCOUD, C. SAINT-LAURENT, E. PICCOLO, M. TAJAN, A. DORTIGNAC, O. PÉREIRA, S. LE GONIDEC, I. BABA, A. GELINEAU, H. ASKIA, M. BRANCHEREAU, J. CHARPENTIER, J. PERSONNAZ, S. BRANKA, J. AURIAU, S. DELERUYELLE, , M. CANOUIL, N. BETON, J.P. SALLES, M. TAUBER, J. WEILL, P. FROGUEL, B.G., NEEL, T. ARAKI, C. HEYMES, R. BURCELIN, I. CASTAN-LAURELL, P. VALET, C. DRAY, E. GAUTIER, T. EDOUARD, J.P. PRADÈRE & A. YART. SHP2 directly drives inflammation-triggered insulin resistance by reshaping tissue macrophage population. Sci. Trans. Med. final revision
F. LABASTE, J. PORTERIE, P. BOUSQUET, B. MARCHEIX, P. SANCHEZ-VERLAAN, B. FRANCES, P. VALET, C. DRAY & V. MINVILLE. Postoperative delirium is a risk factor of poor evolution three years after cardiac surgery: an observational cohort study. Clinical Interventions in Aging
2019
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J. PERSONNAZ, E. PICCOLO, M. BRANCHEREAU, R. PACCOUD, E. MOREAU, B. MASRI, D. CALISE, E. RIANT, P. GOURDY, C. HEYMES, R. SCHWABE, C. DRAY, P. VALET & J.P. PRADÈRE. Macrophage-Derived HMGB1 is dispensable for tissue fibrogenesis. FASEB Bioadvances
I. CASTAN-LAURELL, B. MASRI & P. VALET. The apelin receptor as a therapeutic target in metabolic disease. Expert Opinion on Therapeutic Targets.
C. LEHUEDE, X. LI, S. DAUVILLIER, C. VAYSSE, C. FRANCHET, E. CLEMENT, D. ESTEVE, M. LONGUE, L. CHATIEL, S. LE GONIDEC, I. LAZAR, A. GENESTE, C. DUMONTET, P. VALET, L. NIETO, F. FALLONE & C. MULLER. Adipocytes promote breast cancer resistance to chemotherapy, a process amplified by obesity: role of the major vault protein (MVP). Breast Cancer Research.
A.C. JARRY, N. MERAH, F. CISSE, F. CAYETANOT, M.N. FIAMMA, A. WILLEMETZ, D. GUEDDOURI, B. BARKA, P. VALET, S. GUILMEAU, A. BADO, J. LE BEYEC, L. BODINEAU & M. LE GALL. Neuromedin U is a gut peptide that alters oral glucose tolerance by delaying gastric emptying via direct contraction of the pylorus and vagal-dependent mechanisms, FASEB J.
MORIGNY P, HOUSSIER M, MAIRAL A, GHILAIN C, MOUISEL E, BENHAMED F, MASRI B, RECAZENS E, DENECHAUD P.-D, TAVERNIER G, CASPAR-BAUGUIL S, VIRTUE S, SRAMKOVA V, MONBRUN L, MAZARS A, ZANOUN M, GUILMEAU S, BARQUISSAU V, BEUZELIN D, BONNEL S, MARQUES M, MONGE-ROFFARELLO B, LEFORT C, FIELDING B, SULPICE T, ASTRUP A, PAYRASTRE B, BERTRAND-MICHEL J, MEUGNIER E LIGAT L, LOPEZ F, GUILLOU H, LING C, HOLM C, RABASA-LHORET R, SARIS WHM, STICH V, ARNER P, RYDÉN M, MORO C, VIGUERIE N, HARMS M, HALLÉN S, VIDAL-PUIG A, VIDAL H, POSTIC C, LANGIN D Interaction between Hormone-Sensitive Lipase and ChREBP in Fat Cells Controls Insulin Sensitivity. Nature Metabolism 2019
V. LAURENT, A. TOULET, C. ATTANE, D. MILHAS, S. DAUVILLIER, FALEK ZAIDI, S. LEGONIDEC, A. GUERARD, C. LEHUEDE, D. GARANDEAU, M. CINATO, L. NIETO, E. RENAUD, A.C. PRATS, P. VALET, B. MALAVAUD & C. MULLER. Periprostatic adipose tissue favors prostate cancer cell invasion in an obesity dependent manner: role of oxidative stress. Mol. Cancer Res. 17 : 821-835, 2019.
CABOU C, HONORATO P, BRICEÑO L, GHEZALI L, DUPARC T, LEON M, COMBES G, FRAYSSINHES L, FOURNEL A, ABOT A, MASRI B, PARADA N, AGUILERA V, AGUAYO C, KNAUF C, GONZALEZ M, MARTINEZ LO, RADOJKOVIC C. Pharmacological inhibition of the F1 -ATPase/P2Y1 pathway suppresses the effect of apolipoprotein A1 on endothelial nitric oxide synthesis and vasorelaxation. Acta Physiol (Oxf). 2019
GIROUSSE A, GIL-ORTEGA M, BOURLIER V, BERGEAUD C, SASTOURNE-ARREY Q, MORO C, BARREAU C, GUISSARD C, VION J, ARNAUD E, PRADERE JP, JUIN N, CASTEILLA L, SENGENES C. The Release of Adipose Stromal Cells from Subcutaneous Adipose Tissue Regulates Ectopic Intramuscular Adipocyte Deposition. Cell Rep. 27: 323-333.e5. 2019.
C. VINEL, J.P. SCHANSTRA, F. BOIZAERD, O. PEREIRA, J. AURIAU, A. DORTIGNAC, B. BREUIL, G. FEUILLET, E. NKUIPOU-KENFACK, P. ZURBIG, P. VALET, J.L. BASCANDS, C. DRAY & C. DENIS. Apelin rejuvenates the mouse ageing urinary peptidome without major effects on kidney. Sci. Rep.
MALTAIS M, AUBERTIN-LEHEUDRE M, DRAY C, FIELDING RA, ROLLAND Y, CESARI M, VELLAS B. Highlights from the 2019 International Congress on Frailty and Sarcopenia Research. J. Frailty Aging.
M. BELLIO, C. GARCIA, T. EDOUARD, S. VOISIN, B. NEEL, C. CABOU, P. VALET, J. MORI, A. MAZHARIAN, Y. SENIS, A. YART, B. PAYRASTRE & S. SEVERIN. Catalytic dysregulation of SHP2 leading to Noonan syndromes impacts on platelet signaling and functions. Blood
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C. VINEL, L. LUKJANENK, A. BATUT, S. DELEYRUELLE, J.P. PRADERE, S. LE GONIDEC, A. DORTIGNAC, N. GEOFFRE, O. PEREIRA, S. KARAZ, U. LEE, M. CAMUS, K. CHAOUI, E. MOUISEL, A. BIGOT, V. MOULY, M. VIGNEAU, A. PAGANO, A. CHOPARD, F. PILLARD, S. GUYONNET, M. CESARI, O. SCHILTZ, M. PAHOR, J. FEIGE, B. VELLAS, P. VALET & C. DRAY. The exerkine apelin reverses age-associated sarcopenia. Nat. Med., 24: 1360-1371, 2018.
P. GOURDY, L. CAZALS, C. THALAMAS, A. SOMMET, F. CALVAS, M. GALITZY, C. VINEL, C. DRAY, H. HANAIRE, I. CASTAN-LAURELL & P. VALET. Apelin administration improves insulin sensitivity in overweight men: a randomised trial. Diabetes Obes. Metab. 20: 157-164, 2018
C. BERTRAND, J.P. PRADERE, N. GEOFFRE, S. DELERUYELLE, B. MASRI, J. PERSONNAZ, S. LE GONIDEC, A. BATUT, K. LOUCHE, C. MORO, P. VALET & I. CASTAN-LAURELL. Chronic apelin treatment improves hepatic lipid metabolism in obese and insulin-resistant mice. Endocrine, 60 : 112-121, 2018.
C. VINEL, O. PEREIRA, A. DUPUY, J. BERTRAND-MICHEL, D. LAOUDJ-CHENIVESSE, Y. ROLLAND, D. RIVIÈRE, P. VALET, C. DRAY & F. PILLARD. Isoprostanes as markers of muscle aging process of aged master athletes. Biochimie 6: 1-8, 2018.
A. ABOT, A. LUCAS, T. BAUTZOVA, A. BESSAC, A. FOURNEL, S. LE-GONIDEC, P. VALET, C. MORO, P.D. CANI & C. KNAUF. Galanin modulates the activity of enteric Nitric Oxide Synthase-expressed neurons to control glucose metabolism. Mol. Metab. 10: 100-108, 2018.
A. YART & T. EDOUARD. Noonan syndrome: an update on growth and development. Curr Opin Endocrinol Diabetes Obes. 25: 67-73, 2018.
J. SAUVEUR, E. MATERA, A. CHETTAB, P. VALET, J. GUITTON, A. SAVINA & C. DUMONTET. Esophageal cancer cells resistant to T-DM1 display alterations in cell adhesion and the prostaglandin pathway. Oncotarget. 9: 21141-21155, 2018.
E. RENAUD-GABARDOS, B. LEBAS, F. HANTELYS, F. TATIN, D. CALISE, O. KUNDUZOVA, B. MASRI, F. PUJOL, P. SICARD, P. VALET, J. RONCALLI, X. CHAUFOUR, B. GARMY-SUSINI, A. PARINI & A.C. PRATS. Therapeutic benefit and gene network regulation by combined gene transfer of apelin, FGF2 and SERCA2a into ischemic heart. Mol. Ther. 26 : 902-916, 2018.
C. CARPÉNÉ, J. MERCADER, S. LE GONIDEC, S. SCHAAK, J. MIALET-PEREZ, A. ZAKAROFF-GIRARD & J. GALITZKY. Body fat reduction without cardiovascular alteration in mice under oral treatment by the MAO inhibitor phenelzine. Br J Pharmacol. 175: 2428-2440, 2018
M. TAJAN, J. PERNIN-GRANDJEAN, N. BETON, I. GENNERO, F. CAPILLA, B.G. NEEL, T. ARAKI, P. VALET, M. TAUBER, J.P. SALLES, A. YART & T. EDOUARD. Noonan syndrome-causing SHP2 mutants impair ERK-dependent chondrocyte differentiation during endochondral bone growth. Human Mol. Genet. 27: 2276-2289, 2018
R. PACCOUD, M. TAJAN, S. BRANKA, T. EDOUARD & A. YART. The Rasopathy family: Consequences of germline activation of the RAS/MAPK pathway. Endocrine reviews. 39: 676-700, 2018.
G. ASTRE, S. DELERUYELLE, A. DORTIGNAC, C. BONNET, P. VALET & C. DRAY. Specific natural bioactive type 1 fish collagen peptides (Naticol®) oral treatment prevents obesity and associated disorders in Diet-Induced-Obesity mouse. J. Physiol. Biochem. 74: 647-654, 2018.
V. LAURENT, A. TOULET, C. ATTANE, D. MILHAS, S. DAUVILLIER, FALEK ZAIDI, S. LEGONIDEC, A. GUERARD, C. LEHUEDE, D. GARANDEAU, M. CINATO, L. NIETO, E. RENAUD, A.C. PRATS, P. VALET, B. MALAVAUD & C. MULLER. Periprostatic adipose tissue favors prostate cancer cell invasion in an obesity dependent manner: role of oxidative stress. Mol. Cancer Res.
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E. NKUIPOU-KENFACK, J.P. SCHANSTRA, S. BAJWA, C. VINEL, C. DRAY, P. VALET, J.L. BASCANDS, A. VLAHOU, T. KOECK, M. BORRIES, W. BECHTEL-WALZ, T.B. HUBER, K.L. RUDOLPH, A. PICH, H. MISCHAK, P. ZÜRBIG. The use of urinary peptidomics in the assessment of suitability of mouse models for ageing. Plos One 12: e0166875, 2017.
A. FOURNEL, A. DROUGARD, T. DUPARC, A. MARLIN, S. BRIERLEY, J. CASTRO, S. LE GONIDEC, B. MASRI, A. COLON, A. LUCAS, P. ROUSSET, N. CENAC, N. VERGNOLLE, P. VALET, P.D. CANI & C. KNAUF. Apelin targets gut contraction to control glucose metabolism via the brain. Gut. 66: 258-269, 2017.
K. REKIK, B. FRANCES, P. VALET, C. DRAY & C. FLORIAN. Cognitive deficit in hippocampal-depedent tasks in Werner syndrome mouse model. Behav. Brain Res. 323: 68-77, 2017.
S. LE GONIDEC, C. CHAVES-ALMAGRO, Y. BAI, A. SMITH, E. WANECQ, H. PRATS, B. KNIBIEHLER, L.S. BARAK, M.G. CARON, P. VALET, Y. AUDIGIER & B. MASRI. Anti-angiogenic activity of Protamine relies on apelin receptor antagonism. Faseb J. 31 : 2507-2519, 2017.
A. BINIA, C. VARGAS-MARTINEZ, M. ANCIRA-MORENO, L.M. GOSONIU, I. MONTOLIU, E. GAMEZ-VALDEZ, D.C. SORIA-CONTRERAS, A. ANGELES-QUEZADA, R. GONZALEZ-ALBERTO, S. FERNANDEZ, D. MARTINEZ-CONDE, B. HERNANDEZ-MORAN, M. RAMIREZ-SOLANO, C. PEREZ-ORTEGA, Y. RODRIGUEZ-CARMONA, I. CASTAN, I. RUBIO-ALIAGA, F. VADILLO-ORTEGA, R. MARQUEZ-VELASCO, R. BOJALIL, J.C. LOPEZ-ALVARENGA, P. VALET, M. KUSSMANN, I. SILVA-ZOLEZZI & M.E. TEJERO. Improvement of lipid and glucose metabolism markers after fish oil intervention in healthy Mexican adults and the role of PPARα L162V and PPARγ2 P12A. J. Nutr. Biochem. 43: 98-106, 2017.
O. ZIEGLER, P. BOHME & P. VALET. De la dysfonction du tissu adipeux blanc aux phénotypes anatomo-cliniques de l’obésité. Obésité, 2017.
H. TRONCHERE, M. CINATO, A. TIMOTIN, L. GUITOU, B. PAYRASTRE, P. VALET, A. PARINI, O. KUNDUZOVA & F. BOAL. Inhibition of PIKfyve improves cardiometabolic phenotype in chronic diet-induced obesity through activation of SIRT3. Embo Mol. Med.9: 770-785, 2017
F. LOUIS, P. PANNETIER, Z. SOUGUIR, D. LE CERF, P. VALET, J.P. VANNIER, G. VIDAL & E. DEMANGE. A biomimetic hydrogel functionalized with adipose ECM components as a microenvironment for the 3D culture of human and murine adipocytes. Biotechnol. Bioeng. 114: 1813-1824, 2017
F. TATIN, E. RENAUD-GABARDOS, F. HANTELYS, A.C. GODET, F. MORFOISSE, D. CALISE, P. VALET, B. MASRI, A.C. PRATS & B. GARMY-SUSINI. Apelin controls lymph S1P release and prevents pathological remodeling of lymphatic vasculature in cardiac ischemia. J. Clin. Invest. Insight. 2017.
Y. ROLLAND, C. DUPUY, G.A. VANKAN, M. CESARI, B. VELLAS, M. FARUCH, C. DRAY & P DESOUTO-BARRETO. Sarcopenia screened by the SARC-F questionnaire and physical performances of elderly women : A cross-sectional study. J. Am. Med. Dir. Assoc. 2017
M. VELLAS, C. FUALDES, J.E. MORLEY, C. DRAY, L. RODRIGUEZ-MANAS, A. MEYER, L. MICHEL, Y. ROLLAND & Y. GOURINAT. Aeroaging – A new collaboration betwwen life sciences experts and aerospace engineers. J. Health Nutr. Aging. 2017
E. HARDFORD-WRIGHT, G. ANDRE-GREGOIRE, K.A. JACOBS, L. TREPS, S. LE GONIDEC, H.M. LECLAIR, H.M. LECLAIR, S. GONZALEZ-DIEST, Q. ROUX, F. GUILLONNEAU, D. LOUSSOUARN, L. OLIVIER, F.M. VALLETTE, F. FOUFELLE, P. VALET, A.P. DAVENPORT, R.C. GLEN, N. BIDERE & J. GAVARD. Pharmacological targeting of apelin impairs glioblastoma growth. Brain. 140: 2939-2954, 2017.
2016
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V. LAURENT, A. GUERARD, C. MAZEROLLES, S. LE GONIDEC, L. NIETO, F. ZAIDI, B. MAJED, D. GARANDEAU, Y. SOCRIER, M. GOLZIO, T. CADOUDAL, K. CHAOUI, C. DRAY, O. SCHILTZ, B. COUDERC, P. VALET, B. MALAVAUD & C. MULLER. Periprostatic adipose tissue drives prostate cancer local dissemination through the chemokine receptor CCR3. Nature Com. 7: 10230, 2016.
F. ADAM, A.M. KHATIB, J. JAVIER LOPEZ, C. VATIER, S. TURPIN, A. MUSCAT, F. SOULET, A. ARIES, I. JARDIN, R. BOBE, A. STEPANIAN, D. de PROST, C. DRAY, J. ROSADO, P. VALET, B. FEVE & G. SIEGFRIED. Apelin acts as an antithrombotic factor by inhibiting platelet functions. Blood. 127 : 908-920, 2016.
F. PILLARD, M. LAVIT, V.L. CANCES, J. RAMI, G. HOUIN, A. DIDIER & D. RIVIERE. Medical and pharmacological approach to adjust the salbutamol anti-doping policy in athletes. Respir Res.
F. BOAL, A. TIMOTIN, J. ROUMEGOUX, C. ALFARANO, D. CALISE, R. ANESIA, A. PARINI, P. VALET, H. TRONCHERE, O. KUNDUZOVA. Apelin-13 administration protects against ischemia/reperfusion-mediated apoptosis through FoxO1 pathway in high-fat diet-induced obesity. British J. Pharmacol. 173: 1850-1863, 2016.
A. DUPUY, P. LE FAOUDER, C. VIGOR, C. OGER, J.M. GALANO, C. DRAY, J.C.Y LEE, P. VALET, C. GLADINE, T. DURAND & J. BERTRAND-MICHEL. Simultaneous quantitative profiling of 20 isoprostanoids from omega-3 and omega-6 polyunsaturated fatty acids by LC-MS/MS in various biological samples. Analytica Chimica Acta. 921 : 46-58, 2016.
C. POMIÉ, V. BLASCO-BAQUE, P. KLOPP, S. NICOLAS, A. WAGET, P. LOUBIÈRES, F. LOPEZ, C. DRAY, P. VALET, B. LELOUVIER, F. SERVANT, M. COURTNEY, JACQUES AMAR, R. BURCELIN & L. GARIDOU. Triggering the adaptive immune system with commensal gut bacteria protects against insulin resistance and dysglycemia. Mol. Metab. 28: 392-403, 2016.
N. DALI-YOUCEF, K. HNIA, S. BLAISE, N. MESSADDEQ, S. BLANC, C. POSTIC, P. VALET, C. TOMASETTO & M.C. RIO. Matrix metalloproteinase 11 protects from diabesity and promotes metabolic switch. Sci. Rep. 6 : 25140, 2016.
I. LAZAR, E. CLEMENT, S. DAUVILLIER, D. MILHAS, M. DUCOUX-PETIT, S. LE GONIDEC, C. MORO, V. SOLDAN, S. DALLE, S. BALOR, M. GOLZIO, O. BURLET-SCHILTZ, P. VALET, C. MULLER, & L. NIETO. Adipocyte exosomes promote melanoma aggressiveness through fatty acid oxidation: a novel mechanism linking obesity and cancer. Cancer Res.
F. LES PARELLADA, S. DELERUYELLE, L.E. CASSAGNES, J.A. BOUTIN, B. BALOGH, J.M. ARBONES-MAINAR, S. BIRON, P. MARCEAU, D. RICHARD, F. NEPVEU, P. MAURIEGE & C. CARPENE. Piceatannol and resveratrol share inhibitory effects on hydrogen peroxide release, monoamine oxidase and lipogenic activities in adipose tissue, but differ in their antilipolytic properties. Chem. Biol. Interact.
A. DROUGARD, A. FOURNEL, A. MARLIN, E. MEUNIER, T. DUPARC, K. LOUCHE, A. BATUT, A. LUCAS, S. LE-GONIDEC, J. LESAGE, X. FIORAMONTI, C. MORO, P. VALET, P.D. CANI & C. KNAUF. Central chronic apelin infusion decreases energy expenditure and thermogenesis in mice. Sci. Rep.
C. CESSANS, V. EHLINGER, C. ARNAUD, A. YART, Y. CAPRI, P. BARAT, B. CAMMAS, D. LACOMBE, R. COUTANT, A. DAVID, S. BARON, J. WEILL, B. LEHEUP, M. NICOLINO, J.P. SALLES, A. VERLOES, M. TAUBER, H. CAVE & T. EDOUARD. Growth patterns of patients with Noonan syndrome: correlation with age and genotype. Eur J Endocrinol.
2015
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C. BERTRAND, P. VALET & I. CASTAN-LAURELL. Apelin and energy metabolism. Frontiers in Physiology. 6 : 1-5, 2015.
C. ALFARANO, C. FOUSSAL, O. LAIREZ, D. CALISE, C. ATTANE, R. ANESIA, D. DAVIAUD, E. WANECQ, A. PARINI, P. VALET & O. KUNDUZOVA. Apelin Reverses Cardiac Metabolic Reprogramming in a Model Combining Obesity, Diabetes and Heart Failure.
Int. J. Obes. 39: 312-320, 2015.
O. PISARENKO, V. SHULZHENKO, I. STUDNEVA, Y. PELOGEYKINA, A. TIMOSHIN, R. ANESIA, P. VALET, A. PARINI & O. KUNDUZOVA. Novel Structural Analogues of Apelin-12: Mitochondrial ROS Inhibition and Cardiometabolic Protection in myocardial Ischemia-Reperfusion Injury. British J. Pharmacol. 172: 2933-2945, 2015.
C. REGAZZETTI, K. DUMAS, S. LACAS-GERVAIS, F. PASTOR, P. PERALDI, S. BONNAFOUS, I. DUGAIL, S. LE LAY, P.VALET, Y. LE MARCHAND-BRUSTEL, A. TRAN, P. GUAL, J.F. TANTI, M. CORMONT & S. GIORGETTI-PERALDI. Hypoxia inhibits cavin-1 and cavin-2 expression and downregulates caveolae in adipocytes. Endocrinology. 156 : 789-801, 2015.
B. MASRI, C. DRAY, C. KNAUF, P. VALET & I. CASTAN-LAURELL. Le récepteur de l’apeline : une voie originale dans la stratégie antidiabétique. Médecine/Sciences. 31: 275-81, 2015.
A. DROUGARD, A. FOURNEL, P. VALET & C. KNAUF. Impact of hypothalamic reactive oxygen species in the control of metabolism and food intake. Frontiers in Neurosciences. 9 : 1-12, 2015.
B. MASRI, C. DRAY, I. CASTAN-LAURELL & P. VALET. Apelin receptors: pharmacology, signaling and novel drug discovery. Eur. J. Pharmacol. 763 : 149-159, 2015
L. GARIDOU, C. POMIE, P. KLOPP, A. WAGET, J. CHARPENTIER, M. ALOULOU, A. GIRY, M. SERINO, L. STENMAN, S. LAHTINEN, C. DRAY, J.S. IACOVONI, M. COURTNEY, X. COLLET, J. AMAR, F. SERVANT, B. LELOUVIER, P. VALET, G. EBERL, N. FAZILLEAU, V. DOUIN-ECHINARD, C. HEYMES & R. BURCELIN. The gut microbiota regulates intestinal CD4 T cells, Expressing RORgt and controls metabolic disease. Cell Metab. 22: 100-112, 21015.
N. MAKDISSY, M. YOUNSI, K. HADDAD, C. MOUAWAD, I. POPA, P. VALET, L. BRUNAUD, O. ZIEGLER, M. DONNER & D. QUILLIOT. Regulation of SREBPs by Sphingomyelin in adipocytes via a caveolin-2 and Ras-ERK MAPK CREB signaling pathway. Plos One. 10 : e0133181, 2015.
M. TAJAN, A. DE ROCCA SERRA-NEDELEC, P. VALET, T. EDOUARD & A. YART. SHP2 sails from physiology to pathology. European Journal of Medical Genetics. 58 : 509-525, 2015.
F. BOAL, J. ROUMEGOUX, C. ALFARANO, A. TIMOTIN, D. CALISE, R. ANESIA, A. DROUGARD, C. KNAUF, C. LAGENTE, J. RONCALI, F. DESMOULIN, H. TRONCHERE, P. VALET, A. PARINI & O. KUNDUZOVA. Apelin regulates FoxO3 translocation to mediate cardioprotective responses to myocardial injury and obesity. Sci. Rep. 5 : 16104, 2015.
K. LOLMEDE, A. ZAKAROFF-GIRARD, C. DRAY, M.L. RENOUD, D. DAVIAUD, R. BURCELIN, M. LAFONTAN, J. GALITSKY & A. BOULOUMIE. Interrelationship between lymphocytes and leptin in fat depots of obese mice revealed by changes in nutritional status. J. Physiol. Biochem. 71: 497-507, 2015.
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T. CADOUDAL, M. BULEON, C. SENGENES, F. DESNEULIN, C. MOLINAS, F. CONTE-AURIOL, D. DAVIAUD, P. MARTIN, A. BOULOUMIE, J.P. SALLES, M. TAUBERT & P. VALET. Impairment of adipose tissue in Prader-Willi syndrome rescued by growth hormone treatment. Int. J. Obes. 38: 1234-1240, 2014.
C. RANCOULE, M. VIAUD, S. GRES, N. VIGUERIE, P. DECAUNES, A. BOULOUMIE, D. LANGIN, J.L. BASCANDS, P. VALET, J.S. SAULNIER-BLACHE. Pro-fibrotic activity of Lysophosphatidic acid in Adipose tissue: in vivo and in vitro evidence. Bioch. Biophys. Acta. 1841: 88-96, 2014.
A.T. NGUYEN, S. MANDARD, C. DRAY, V. DECKERT, P. VALET, D. J DRUCKER, L. LAGROST & J. GROBER. LPS-mediated increase in glucose-stimulated insulin secretion: Involvement of the glucagon-like peptide 1 (GLP-1) pathway. Diabetes, 63 : 471-482, 2014.
I. OLIVIER, V. THEODOROU, P. VALET, I. CASTAN-LAURELL, L. FERRIER & H. EUTAMENE. Modifications of mesenteric adipose tissue during moderate experimental colitis in mice. Life Sci. 94 : 1-7, 2014.
C. RANCOULE, R. DUSAULCY, K. TREGUER, S. GRES, C. ATTANE & J.S. SAULNIER-BLACHE. Involvement of autotaxin/lysophosphatidic acid signaling in obesity and impaired glucose homeostasis. Biochimie. 96: 140-3, 2014.
A. DROUGARD, T. DUPARC, X. BRENACHOT, L. CARNEIRO, A. GOUAZÉ, A. FOURNEL, L. GEURTS, T. CADOUDAL, A.C. PRATS, L. PÉNICAUD, D. VIEAU, J. LESAGE, C. LELOUP, A. BENANI, P.D. CANI, P. VALET & C. KNAUF. Hypothalamic apelin/ros signaling controls hepatic glucose metabolism in the onset of diabetes. Antiox. Red. Signal. 20: 555-573, 2014.
A. BESSE-PATIN, E. MONTASTIER, C. VINEL, I. CASTAN-LAURELL, K. LOUCHE, C. DRAY, D. DAVIAUD, L. MIR, M.A. MARQUES, C. THALAMAS, P. VALET, D. LANGIN, C. MORO & N. VIGUERIE. Effect of endurance training on skeletal muscle myokine expression in obese men: identification of apelin as a novel myokine. Int. J. Obes. 38 : 707-713, 2014.
G.NICHOLSON, K.E. PINNICK, K. MANOLOPOULOS, S. MCQUAID, P. VALET, K. FRAYN, J.L. MIN, K.T. ZONDERVAN, J. FLECKNER, THE MOLPAGE CONSORTIUM, M.I. MCCARTHY, C.C. HOLMES, F. KARPE. Gluteofemoral adipose tissue resists molecular adaptations associated with obesity-related complications. Diabetes 63 : 3785-3797, 2014.
S. LABIALLE, V. MARTY, M.L. BORTOLIN-CAVAILLE, M. HOAREAU-OSMAN, J.P. PRADERE, P. VALET, G.P. MARTIN & J. CAVAILLE. The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain controls neonatal metabolic adaptation. EMBO J. 6: 1328-1346, 2014.
L. LAPEIRE, A. HENDRIX, K. LAMBEIN, M. VAN BOCKSTAL, G. BRAEMS, R. VAN DEN BROECKE, R. LIMAME, P. MESTDAGH, J. VANDESOMPELE, C. VANHOVE, D. MAYNARD, C. MULLER, P. VALET, C. GESPACH, M. BRACKE, V. COCQUYT, H. DENYS & O. DE WEVER. Cancer-associated adipose tissue promotes breast cancer progression by paracrine Oncostatin M and JAK3/STAT3 signaling. Cancer Res. 74: 6806-6819-2014.
A. ABOT, C. FONTAINE, R. SOLINHAC, A. DROUGARD, A. FABRE, S. RAJAN, M. LAINE, M. BUSCATO, A. MILON, D. HENRION, M. MESTDAGT, I. RAYMOND-LETRON, C. KNAUF, P. GOURDY, G. FLOURIOT, P. VALET, B.S. KATZENELLENBOGEN, J.A. KATZENELLENBOGEN, F. LENFANT, G.L. GREENE, J.M. FOIDART & J.F. ARNAL. The uterine and vascular actions of Estetrol delineate a distinctive profile of Estrogen Receptor α modulation, uncoupling nuclear and membrane activation. EMBO Mol. Med. 6: 1328-1346, 2014.
M. TAJAN, T. CADOUDAL, A. BATUT, S. DELERUYELLE, S. LE GONIDEC, C. SAINT LAURENT, M. VOMSCHEID, E. WANECQ, K. TREGUER, A . DE ROCCA SERRA-NEDELEC, C. VINEL, M.A. MARQUES, J. POZZO, O. KUNDUZOVA , J.P. SALLES, M. TAUBER, P.RAYNAL, H. CAVE, T. EDOUARD, P. VALET & A. YART. LEOPARD syndrome-associated SHP2 mutation confers leanness and protection from diet-induced obesity. PNAS. 111: E4494-E4503, 2014.
2013
L. BUTRUILLE, S. MAYEUR, E. MOITROT, L. STORME, C. KNAUF, J. LESAGE, P. DERUELLE. Maternal hypertension induced by NO blockade did not program adult metabolic diseases in growth-restricted rat fetuses without limb defects. Metabolism. 46 : 94-101, 2013
C. CARPENE, S. GRES & S.RASCALOU. The amine oxidase inhibitor phenelzine limits lipogenesis in adipocytes without inhibiting insulin action on glucose uptake. J. Neural. Transm., 120: 997-1003, 2013.
S. GRES, S. GOMEZ-ZORITA, A. GOMEZ-RUIZ & C.CARPENE. 5-hydroxytryptamine actions in adipocytes: involvement of monoamine oxidase-dependent oxidation and subsequent PPARγ activation. J. Neural. Transm., 120: 919-26, 2013.
S. GOMEZ-ZORITA, K.TREGUER, J.MERCADER & C. CARPENE. Resveratrol directly affects in vitro lipolysis and glucose transport in human fat cells. J. Physiol. Biochem., 69: 585-93, 2013.
C. RANCOULE, C. ATTANE, S. GRES, A. FOURNEL, R. DUSAULCY, C. BERTRAND, C. VINEL, K. TREGUER, M. PRENTKI, P. VALET & J.S. SAULNIER-BLACHE. Lysophosphatidic acid impairs glucose homeostasis and inhibits insulin secretion in high fat diet obese mice. Diabetologia, 56 : 1394-1402, 2013.
I. WOCLAWEK-POTOCKA, D. BORUSZEWSKA, I. KOWALCZYK-ZIEBA, K.PIOTROWSKA-TOMALA, JS. SAULNIER BLACHE, D.J. SKARZYNSKI . Which bovine endometrial cells are the source of and target for lysophosphatidic acid ? Reprod. Biol. 13: 100-103, 2013.
L. BOCHET, C. LEHUEDE, S. DAUVILLIER, Y.Y. WANG, B. DIRAT, V. LAURENT, M. DABEK, C. DRAY, R. GUIET, I. MARIDONNEAU-PARINI, S. LE GONIDEC, G. ESCOURROU, P. VALET & C. MULLER. Adipocyte-Derived Fibroblasts (ADFs), a new stromal cell population, promote tumor progression and contribute to desmoplastic reaction in breast cancer. Cancer Res. 73 : 5657-5668, 2013.
L. BUTRUILLE, A. DROUGARD, C. KNAUF, E. MOITROT, P. VALET, L. STORME, P. DERUELLE, J. LESAGE. The apelinergic system: Sexual dimorphism and tissue-specific modulations by obesity and insulin resistance in female mice. Peptides 46 : 94-101, 2013
E. LUCHE, B. COUSIN, L. GARIDOU, M. SERINO, A. WAGET, C. BARREAU, M. ANDRE, P. VALET, M. COURTNEY, L. CASTEILLA & R. BURCELIN. Metabolic endotoxemia directly increases the proliferation of adipocyte precursors at the onset of metabolic diseases through a CD14-dependent mechanism. Mol. Metab. 2 : 281-291, 2013.
J .S. WATTEZ, R. RAVALLEC, B. CUDENNEC, C. KNAUF, P. DHULSTER, P. VALET, C. BRETON, D. VIEAU & J. LESAGE. Apelin stimulates both cholecystokinin and glucagon-like peptide 1 secretions in vitro and in vivo in rodents. Peptides 48 : 134-136, 2013.
C. SZATKOWSKI, P. VALET, N. MESSADEQ, M. DORMISHIAN, M. BOULBERDAA, D. METZGER, P. CHAMBON, C.G. NEBIGIL. Prokineticin receptor-1 (PKR1) as a new suppressor in preadipocyte conversion to adipocytes. Plos One 8 : e81175, 2013.
C. KNAUF, A. DROUGARD, A. FOURNEL, T. DUPARC & P. VALET. Hypothalamic actions of apelin on energy metabolism: New insight on glucose homeostasis and metabolic disorders. Horm. Metab. Res.
C. BERTRAND, A. PIGNALOSA, E. WANECQ, C. RANCOULE, A. BATUT, S. DELERUYELLE, L. LIONETTI, P. VALET & I. CASTAN-LAURELL. Effects of dietary EicosaPentaenoic Acid (EPA) supplementation on apelin and metabolism in muscle of high-fat fed mice. Plos One. 8 : e78874, 2013.
2012
D. PCHEJETSKI, C. FOUSSAL, C. ALFARANO, D. CALISE, C. GUILBEAU-FRUGIER, M.H. SEGUELAS, P. VALET, A. PARINI &O. KUNDUZOVA. Apelin prevents cardiac fibroblast activation and collagen production through inhibition of sphingosine kinase 1. Eur. Heart J. 33: 2360-2369, 2012.
M. SERINO, E. LUCHE, S. GRES, A. BAYLAC, M. BERGE, C. CENAC, A. WAGET, P. KLOPP, J. IACOVONI, C. KLOPP, J. MARIETTE, O. BOUCHEZ, J. LLUCH, F. OUARNE, P. MONSAN, P. VALET, C. ROQUES, J. AMAR , A. BOULOUMIE, V. THEODOROU & R. BURCELIN. Metabolic Adaptation to High-Fat Diet is Associated with Gut Microbiota Change. Gut. 61 : 543-553, 2012.
P. STUCCHI, M. GIL-ORTEGA, B. MERINO, R. GUZMÁN-RUIZ, V. CANO, I. VALLADOLID-ACEBES, B. SOMOZA, S. LE GONIDEC, J. ARGENTE, P. VALET, J.A. CHOWEN, M. FERNÁNDEZ-ALFONSO & M. RUIZ-GAYO. Circadian feeding-drive of metabolic activity in adipose tissue and not hyperphagia triggers overweight in mice. Is there a role of the pentose-phosphate pathway? Endocrinology 153: 690-699, 2012.
R. AWADA, P. RONDEAU, S. GRES, J.S. SAULNIER-BLACHE, C. LEFEBVRE D’HELLENCOURT & E. BOURDON. Autotaxin protects microglial cells against oxidative stress. Free Radical Biol. & Med.
A. DE ROCCA SERRA-NEDELEC, T. EDOUARD, K. TREGUER, M. TAJAN, M. DANCE, M. MUS, M. TAUBER, J.P. SALLES, P. VALET, B.G. NEEL, P. RAYNAL & A. YART. Noonan syndrome causing-SHP2 mutations inhibit IGF-I release through GH-induced Ras/MAPK hyperactivation: a molecular explanation for growth retardation in Noonan syndrome? Proc. Nat. Acad. Sci. 109: 4257-4262, 2012.
C. CARPENE, A. DESQUESNES, A. GOMEZ-RUIZ, Z. IFFIU-SOLTESZ, S. LE GONIDEC & J. MERCADER. Long-term activation of semicarbazide-sensitive amine oxidase lowers circulating levels of uric acid in diabetic conditions. Physiol. Res., 2012
J. IVARS, L. BUTRUILLE, C. KNAUF, T. BOUCKENOOGHE, S. MAYEUR, D. VIEAU, P. VALET, P. DERUELLE & J. LESAGE. Maternal hypertension induces tissue-specific modulations of the apelinergic system in the fetoplacental unit in rat. Peptides. 35 : 136-138, 2012.
I. CASTAN-LAURELL, C DRAY, C. KNAUF, O. KUNDUZOVA & P. VALET. Apelin, a promising target for the treatment of type 2 diabetes. Trends In Endocrinol. Metab., 23 : 234-241, 2012.
S. GRES, S. BOUR, P. VALET & C. CARPENE. Benzylamine antihyperglycemic effect is abolished by AOC3 gene invalidation in mice but not rescued by semicarbazide-sensitive amine oxidase expression Under the control of the aP2 promoter. J. Physiol. Biochem.
L. BUTRUILLE, S. MAYEUR, T. DUPARC, C. KNAUF, E. MOITROT, I. FAJARDY, P. VALET, L. STORME, P. DERUELLE & J. LESAGE. Prenatal Fasudil exposure alleviates fetal growth but programs hyperphagia and overweight in the adult male rat. Eur J. Pharmacol. 689: 278-84, 2012.
Y.Y. WANG, C. LEHUEDE, V. LAURENT, B. DIRAT, S. DAUVILLIER, L. BOCHET, S. LE GONIDEC, G. ESCOURROU, P. VALET & C. MULLER.Adipose tissue and breast epithelial cells: a dangerous dynamic duo in breast cancer. Cancer let. 324: 142-51, 2012.
C. RANCOULE, R. DUSAULCY, K. TREGUER, S. GRES, C. GUIGNE, D. QUILLIOT, P. VALET & J.S. SAULNIER-BLACHE. Depot-specific regulation of autotaxin with obesity in human adipose tissue. J. Physiol. Biochem.
C. VILLENEUVE, C. GUILBEAU-FRUGIER, O. LAIREZ, C. ORDENER, T. DUPARC, D. DE PAULIS, B. COUDERC, O. SPREUX-VAROQUEAUX, C. KNAUF, A. GHARIB, P. VALET, M. OVIZE, C. NEDIANI, M.B. DELISLE, A. PARINI, J. MIALET-PEREZ. p53-PGC-1alpha pathway mediates oxidative mitochondrial damage and cardiomyocyte necrosis induced by monoamine oxidase-A upregulation: role in chronic left ventricular dysfunction in mice. Antiox. Red. Signal.
A. BENANI, C. HRYHROCZUK, A. GOUAZE, X. FIORAMONTI, C. GUISSARD, A. KREZYMON, X. BRENACHOT, T. DUPARC, A. COLOM, E. NEDELEC, C. RIGAULT, A. LEMOINE, J. GASCUEL, R. GERARDY-SCHAHN, P. VALET, C. KNAUF, A. LORSIGNOL & L. PENICAUD. Food intake adaptation to dietary fat involves PSA-dependant rewiring of the arcuate melanocortin system in mice. J. Neuroscience. 32 : 11970-11979, 2012.
R. TEPERINO, S. AMANN, M. BAYER, S.L. MCGEE, A. LOIPETZBERGER, C. JAEGER, B. KAMMERER, M.A. FEBBRAIO, C. KNAUF, P.D. CANI, F. ABERGER, J.M. PENNINGER, J. A. POSPISILIK & H. ESTERBAUER. Rapid rewiring of adipocyte metabolism by a novel Hedgehog-Smoothened-AMPK axis. Cell
K. NADRA, J.J. MEDARD, J.D. MUL, G.S. HAN, S. GRES, M. PENDE, D. METZGER, P. CHAMBON, E. CUPPEN, J.S. SAULNIER-BLACHE, G.M. CARMAN, B. DESVERGNE, R. CHRAST. Cell autonomous lipin 1 function is essential for development and maintenance of white and brown adipose tissue. Mol. Cell. Biol. 32: 4794-810, 2012.
A. GAAYA, O. POIRIER, N. MOUGENOT, T. HERY, F. ATASSI, A. MARCHAND, J.S. SAULNIER-BLACHE, J. AMOUR, J. VOGT, A.M. LOMPRE, F. SOUBRIER, S. NADAUD. Plasticity-related gene-1 inhibits lysophosphatidic acid-induced vascular smooth muscle cell migration and proliferation and prevents neointima formation. Am. J. Physiol. Cell. Physiol. 303:C1104-1114, 2012.
I. KOWALCZYK-ZIEBA, D. BORUSZEWSKA, J.S. SAULNIER-BLACHE, L. LOPES DA COSTA, K. JANKOWSKA, D.J. SKARZYNSKI, I. WOCLAWEK-POTOCKA. Lysophosphatidic Acid Action in the Bovine Corpus Luteum-An In Vitro Study. J. Reprod. Dev. 58: 661-71, 2012
2011
T. DUPARC, D. NASLAIN, A. COLOM, G.G. MUCCIOLI, N. MASSALY, N.M. DELZENNE, P. VALET, P.D. CANI, C. KNAUF. Jejunum inflammation in obese and diabetic mice impairs enteric glucose detection and modifies nitric oxide release in the hypothalamus. Antiox. Red. Signal 14: 415-423, 2011.
C. RANCOULE, J .P. PRADERE, J. GONZALEZ, J. KLEIN, P. VALET, J.L. BASCANDS, J.P. SCHANSTRA & J.S. SAULNIER-BLACHE. Lysophosphatidic acid-1-receptor targeting agents forfibrosis. Expert Opin Investig Drugs. 20: 657-67, 2011.
I. OLIVIER, V. THEODOROU, P. VALET, I. CASTAN-LAURELL, H. GUILLOU, J. BERTRAND-MICHEL, C. CARTIER, V. BEZIRARD, R. DUCROC, J.P. SEGAIN, G. PORTIER, S. KIRZIN, J. MOREAU, J.P. DUFFAS, L. FERRIER & H. EUTAMENE.Is Crohn’s creeping fat an adipose tissue? Inflam. Bowel. Diseases. 17: 747-757, 2011.
M. CLARET, M.A. SMITH, C. KNAUF, A. WOODS, H. AL- QASSAB, A. HESLEGRAVE, K. PIIPARI, A. COLOM, P. VALET, P.D. CANI, P. MUCKET, M. PETERS, K. MIZUNO, R.L. BATTERHAM, K.P. GIESE, A. ASHWORTH, R. BURCELIN, M.L.J. ASHFORD, D. CARLING& D.J. WITHERS.Deletion of Lkb1 in POMC neurons impairs peripheral glucose homeostasis in mice. Diabetes. 60: 735-45, 2011.
O. MASSON, C. PREBOIS, D. DEROCQ, A. MEULLE,C. DRAY, D. DAVIAUD, D. QUILLIOT, P. VALET, C. MULLER, E. LIAUDET-COOPMAN. Cathepsin-D, a key protease in breast cancer, is up-regulated in obese mouse and human adipose tissue, and controls adipogenesis. PLoS One, 6: 16452, 2011.
Z. IFFIU-SOLTESZ, J. MERCADER, D. DAVIAUD, J. BOUCHER & C. CARPENE. Increased primary amine oxidase expression and activity in white adipose tissue of obese and diabetic db-/- mice. J Neural Transm. 118 : 1071-1077, 2011.
B. DIRAT, L. BOCHET, M. DABEK, D. DAVIAUD, S. DAUVILLIER, B. MAJED, Y.Y. WANG, A. MEULLE, B. SALLES, S. LE GONIDEC, I. GARRIDO, G. ESCOURROU, P. VALET & C. MULLER. Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion. Cancer Res. 71 : 2455-2465, 2011.
T. DUPARC, A. COLOM, P.D. CANI, N. MASSALY, S. RASTRELLI, A. DROUGARD,S. LE GONIDEC, L. MOULÉDOUS, B. FRANCES, I. LECLERCQ, C. LLORENS-CORTES, J.A. POSPISILIK, N.M. DELZENNE, P. VALET, I. CASTAN-LAURELL & C. KNAUF. Central apelin controls glucose homeostasis via a nitric oxide dependent pathway in mice. Antiox. Red. Signal. 15: 1477-1496, 2011.
Z. ZHOU, P. SUBRAMANIAN, G. SEVILMIS, B. GLOBKE, O. SOEHNLEIN, E. KARSHOVSKA, R. MEGENS, K. HEYLL, J. CHUN, J.S. SAULNIER-BLACHE, M. REINHOLZ, M. VAN ZANDVOORT, C. WEBER & A. SCHOBER. Lipoprotein-derived lysophosphatidic acid promotes atherosclerosis by relaxing CXCL1 from the endothelium. Cell Metab. 13: 592-600, 2011.
R. DUSAULCY, S. GRES, E. WANECQ, A. COLOM, C. GUIGNE, L.A. VAN MEETEREN, W.H. MOOLENAAR, P. VALET, J.S. SAULNIER-BLACHE. Adipose-specific disruption of Autotaxin enhances nutritionalfattening and reduces plasma LPA. J. Lipid. Res. 52 : 1247-1255, 2011.
J.D. MUL, K. NADRA, N.B. JAGALUR, I.J. NIJMAN, P.W. TOONEN, J.J. MEDARD, S. GRES, A. DE BRUIN, G. SOO HAN, J.F. BROUWERS, G.M. CARMAN, J.S. SAULNIER-BLACHE, D. MEIJER, R. CHRAST & E. CUPPEN. A hypomorphic mutation in Lpin1 induces progressively improving neuropathy and lipodystrophy in the rat J. Biol. Chem. 286 : 26781-26793, 2011.
L. BOCHET, A. MEULLE, S. IMBERT, B. SALLES, P. VALET & C. MULLER. Cancer-Associated adipocytes promotes breast tumor radiorésistance. Biochem. Biophys. Res. Com. 411: 102-106, 2011.
MERCADER J., WANECQ E., CHEN J. & CARPENE C. Isopropylnorsynephrine is a stronger lipolytic agent in human adipocytes than synephrine and other amines present in Citrus aurantium. J. Physiol. Biochem., 2011, 67, 443-452.
A. REAUX-LE GOAZIGO, L. BODINEAU,N. PICCO,L. JEANDEL, N. CHARTREL, C. KNAUF, C. RAAD, P. VALET & C. LLORENS CORTES. Apelin and the proopiomelanocortin system: a new regulatory pathway of hypothalamic α -msh release. Am. J. Physiol. Endocrinol. Metab. 301: E955-E966, 2011.
L. GEURTS, V. LAZAREVIC, M. DERRIEN, A. EVERARD, M. VAN-ROYE, C. KNAUF, P. VALET, M. GIRARD, G. G MUCCIOLI, P. FRANCOIS, W. M DE VOS, J. SCHRENZEL, N. M DELZENNE & P.D. CANI. Altered gut microbiota and endocannabinoid system tone in obese and diabetic leptin-resistant mice: impact on apelin regulation in adipose tissue. Frontier in cell. and inf. microbiol. 2 : (149) : 1-17, 2011.
J. MERCADER, Z. IFFIU-SOLTESZ, S. BOUR & C. CARPENE. Oral administration of semicarbazide limits weight gain, together with inhibition of fat deposition and of primary amine oxidase activity in adipose tissue. J. Obes., 2011
2010
C. Foussal, O. Lairez, D. Calise, A. Pathak, C. Guilbeau-Frugier, M. Seguelas, P. Valet, A. Parini & O. Kunduzova. Apelin is a key regulator of cardiac antioxidant defense and hypertrophic remodeling. FEBS. 584: 2363-2370, 2010.
Garcia Barrado M. J., Pastor M. F., Iglesias-Osma M. C., Carpéné C. & Moratinos J.: Comparative effects of idazoxan, efaroxan, and BU 224 on insulin secretion in the rabbit: not only interaction with pancreatic imidazoline I2 binding sites. Health, 2: 112-121, 2010.
X. FIORAMONTI, N. MARSOLLIER, Z. SONG, K.A. FAKIRA, R. PATEL, S. BROWN, T. DUPARC, A. PICA-MENDEZ, N.M. SANDERS, C. KNAUF, P. VALET, R.J. McCRIMMON, A. BEUVE, C. MAGNAN & V.H. ROUTH. Ventromedial hypothalamic nitric oxide production is necessary for hypoglycemia detection and counter-regulation. Diabetes, 59: 519-528, 2010.
R. GUZMÁN-RUIZ, B. SOMOZA, M. GIL-ORTEGA, B. MERINO, V. CANO, C. ATTANÉ, I. CASTAN-LAURELL, P. VALET, M.S. FERNÁNDEZ-ALFONSO & M. RUIZ-GAYO. Sensitivity of cardiac carnitine palmitoyltransferase to malonyl-CoA is regulated by leptin: similarities with a model of endogenous hyperleptinemia. Endocrinology, 151: 1010-1018, 2010.
J.A. POSPISILIK, D. SCHRAMEK, H. SCHNIDAR, S.J.F. CRONIN, N.T. NEHME, X. ZHANG, C. KNAUF, P.D. CANI, K. AUMAYR, J. TODORIC, M. BAYER, A. HASCHEMI, M. ORTHOFER, G.G. NEELY, G. DIETZL, A. MANOUKIAN, M. FUNOVICS, G. PRAGER, O. WAGNER, D. FERRANDON, F. ABERGER, C. HUI, H. ESTERBAUER, J.M. PENNINGER. Drosophila whole genome screen reveals Hedgehog-signaling as a key regulator of brown/white adipose cell fate. Cell, 140 : 148-160, 2010.
Z. IFFIU-SOLTESZ, E. WANECQ, A. LOMBA, M.P. PORTILLO, F. PELLATI, E. SZÖKÖ, S. BOUR, J.F. WOODLEY, F.I. MILAGRO, A.J. MARTINEZ, P. VALET & C. CARPENE. Chronic benzylamine administration in the drinking water improves glucose tolerance, reduces body weight gain and circulating cholesterol in high-fat diet-fed mice. Pharmacol. Res. 61 :355-363, 2010.
M. Bot, I. Bot, R. Lopez-Vales, C.H.A. Van de Lest, J.S. Saulnier-Blache, J.B. Helms, S. David, T.J.C. Van Berkel & E.A.L. Biessen. Atherosclerotic Lesion Progression Changes Lysophosphatidic Acid Homeostasis to Favor Its Accumulation. Am. J. Pathol. 176: 3073-3084, 2010.
M. DAVID, E. WANNECQ, F. DESCOTES, S. JANSEN, B. DEUX, J. RIBEIRO, C.M. SERRE, S GRES, N. BENDRISS-VERMARE, M. BOLLEN, S. SAEZ, J. AOKI, J.S. SAULNIER-BLACHE, P. CLEZARDIN & O. PEYRUCHAUD. Cancer cell expression of autotaxin controls bone metastasis formation in mouse through lysophosphatidic acid-dependent activation of osteoclasts. Plos One. 5: e9741, 2010.
M. OUSSET, F. BOUQUET, F. FALLONE, D. BIARD, C. DRAY, P. VALET, B. SALLES & C. MULLER. Loss of ATM positively regulates the expression of Hypoxia Inducible Factor (HIF) 1 through oxidative stress: role in the physiopathology of the disease.Cell Cycle. 9: 2814-2822, 2010.
C. RINGSTRÖM, M.D. NITERT, H. BENNET, M. FEX, P. VALET, J.F. REHFELD, L. FRIIS-HANSEN & N. WIERUP. Apelin is a novel islet peptide. Reg. Pep.162: 44-51, 2010.
J. MERCADER, Z. IFFIU-SOLTESZ, X. BRENACHOT, A. FÖLDI, P. DUNKEL, B. BALOGH, C. ATTANE, P. VALET, P. MATYUS & C. CARPENE. SSAO substrates exhibiting insulin-like effects in adipocytes as a promising treatment option for metabolic disorders. Future Med. Chemistry. 2 : 1735-1749, 2010.
2009
Caspar-Bauguil S., Cousin B., Bour S., Casteilla L., Penicaud L. & Carpéné C. : Adipose tissue lymphocytes: types and roles. J. Physiol. Biochem., 2009, in press.
Wanecq E., Prévot D. & Carpéné C.: Lack of direct insulin-like action of visfatin/Nampt/PBEF1 in human adipocytes. J. Physiol. Biochem., 2009, in press.
Atgié C., Sauvant P., Ambid L. & Carpéné C.: Weight loss of Siberian hamsters (Phodopus sungorus sungorus) exposed to short photoperiod cannot be explained by alteration of antilipolytic or “de novo” lipogenic activities in white adipocytes. J. Physiol. Biochem., 2009, in press.
Iffiú-Soltész Z., Wanecq E., Prévot D., Grès S. & Carpéné C. Histamine oxidation in mouse adipose tissue is controlled by the AOC3 gene-encoded amine oxidase. Inflamm. Res., 2009, in press.
C. Dray, A. Colom, C. Guigné, S. Le gonidec, A. Guibert, F. Ouarne, P. Valet: Native fructose extracted from apple improves glucose tolerance in mice. J. Physiol. Biochem. 65: 361-8, 2009.
Iffiú-Soltész Z., Prévot D. & Carpéné C. :Influence of prolonged fasting on monoamine oxidase and semicarbazide-sensitive amine oxidase activities in rat white adipose tissue. J. Physiol. Biochem., 2009, 65, 11-23.
O. MASSON, C. CHAVEY, C. DRAY, A. MEULLE, D. DAVIAUD, D. QUILLIOT, C. MULLER, P. VALET & E. LIAUDET-COOPMAN. LRP1 gene expression is up-regulated in obese human and mouse adipose tissue and controls adipogenesis. PLoS One, 4: e7422, 2009.
S. BOUR, S. CASPAR-BAUGUIL, Z. IFFIU-SOLTESZ, M. NIBBELINK, B. COUSIN, M. MIILUNIEMI, M. SALMI, C. STOLEN, S. JALKANEN, L. CASTEILLA, L. PENICAUD, P. VALET & C. CARPENE. SSAO/VAP-1 deficiency causes mild obesity without increased leukocyte infiltration into adipose tissue. Am. J. Pathol. 174: 1075-1083, 2009.
F. CHICHE, M. LE GUILLOU, G. CHETRITE, F. LASNIER, I. DUGAIL, C. CARPENE, M. MOLDES & B. FEVE. The antidepressant phenelzine alters differentiation of cultured human and mouse preadipocytes. Mol. Pharmacol. 75 : 1052-1061, 2009.
I. WOCLAWEK-POTOCKA, J. KOMIYAMA, J.S. SAULNIER-BLACHE, E. BRZEZICKA, M. BAH, K. OKUDA, D. SKARZYNSKI. Lysophosphatic acid modulates prostaglandin secretion in the bovine uterus. Reproduction. 137: 95-105, 2009.
E. BOUTET, H. EL MOURABIT, M. PROT, M. NEMANI, E. KHALLOUF, O. COLARD, M. LE MAURICE, A.M. DURAND-SCHNEIDER, Y. CHRETIEN, S. GRES, C. WOLF, J.S. SAULNIER-BLACHE, J. CAPEAU, J. MAGRE. Seipin deficiency alters fatty acid D9 desaturation and lipid droplet formation in Berardinelli-Seip congenital lipodystrophy. Biochime. 91 : 796-803, 2009.
2008
C. DRAY, C. KNAUF, D. DAVIAUD, A. WAGET, M. BULÉON, J. BOUCHER, P. CANI, C. ATTANE, C. GUIGNÉ, C. CARPÉNÉ, R. BURCELIN, I. CASTAN-LAURELL & P. VALET. Apelin stimulates glucose utilization in normal and obese insulin-resistant mice. Cell Metab. 8: 437-445, 2008.
I. CASTAN-LAURELL, M. VITKOVA, D. DAVIAUD, C. DRAY, M. KOVACIKOVA, Z. KOVACOVA, J. HEJNOVA, V. STICH & P. VALET. Effect of hypocaloric diet-induced weight loss in obese women on plasma apelin and adipose tissue expression of apelin and APJ. Eur. J. Endocrinol. 158: 905-910, 2008.
A. MAZZUCOTELLI, C. RIBET, I. CASTAN-LAURELL, D. DAVIAUD, C. GUIGNE, D LANGIN & P. VALET. The transcriptional co-activator PGC-1a up regulates apelin in human and mouse adipocytes. Reg. Pep. 150 : 33-37, 2008.
O. KUNDUZOVA, N. ALET, N. DELESQUE-TOUCHARD, L. MILLET, C. DRAY, C. MULLER, I. CASTAN-LAURELL, P. SCHAEFFER, J.P. HERAULT, P. SAVI, F. BONO & P. VALET. Apelin/APJ signaling system: a potential link between adipose tissue and endothelial angiogenic processes. FASEB J. 22 : 4146-4153, 2008.
G. FERRY, N. MOULHARAT, J.P. PRADERE, P. DESOS, A. TRY, A. GENTON, A. GIGANTI, M. BLEUCHER-GAUDIN, M. LONCHAMPT, M. BERTRAND, J.S. SAULNIER-BLACHE, G.C. TUCKER, A. CORDI, J.A. BOUTIN. S32826 : a nanomolar inhibitor of autotaxin. discovery, synthesis and applications as a pharmacological tool. J. Pharmacol. Exp. Ther. 327 : 809-819, 2008.
J.P. PRADERE, J. GONZALES, J. KLEIN, P. VALET, S. GRES, D. SALANT, J.L. BASCANDS, J.S. SAULNIER-BLACHE & J. SCHANSTRA. LPA and Kidney fibrosis. Biochem. Biophys. Acta. 1781: 582-587, 2008.
L.A. VAN MEETEREN, V. BRINKMANN, J.S. SAULNIER-BLACHE, K.R. LYNCH & V.H. MOOLENAR. FTY720-phosphate inhibits the activity of autotaxin, a metastasis-enhancing lysophospholipase D. Cancer Letters. 266: 203-208, 2008.
C. KNAUF, P.D. CANI, A. AIT-BELGNAOUI, A. BENANI, C. DRAY, C. CABOU, A. COLOM, M. ULDRY, S. RASTRELLI, E. SABATIER, N. GODET, A. WAGET, L. PENICAUD, P. VALET & R. BURCELIN. Brain GLP-1 signaling controls the onset of high-fat diet-induced hyperinsulinemia, insulin resistance and reduced energy expenditure. Endocrinology. 149: 4768-4777, 2008.
A. MEULE, B. SALLES, D. DAVIAUD, P. VALET & C. MULLER. Positive regulation of DNA double strand break repair activity during adipogenesis : implication of the DNA dependent protein kinase. PLoS ONE, 3 : e3345, 2008.
C. CARPENE, V. ABELLO, Z. IFFIU-SOLTESZ, N. MERCIER, B. FEVE & P. VALET. Limitation of adipose tissue enlargement in rats chronically treated with semicarbazide-sensitive amine oxidase and monoamine oxidase inhibitors. Pharmacol. Res. 57: 426-434, 2008.
A.E. BIGORGNE, L. BOUCHET-DELBOS, S. NAVEAU, I. DAGHER, S. PREVOT, I. DURAND-GASSELIN, J. COUDERC, P. VALET, D. EMILIE & G. PERLEMUTER. Obesity-induced lymphocyte hyperresponsiveness to chemokines: a new mechanism of fatty liver inflammation in ob/ob mice. Gastroenterology. 134: 1459-1469, 2008.
A. GIGANTI, M. RODRIGUEZ, B. FOULD, N. MOULHARAT, F. COGÉ, P. CHOMARAT, J.P. GALIZZI, P. VALET, J.S. SAULNIER-BLACHE, J.A. BOUTIN & G. FERRY. Murine and Human Autotaxin alpha, beta, gamma isoforms: gene organization, tissue distribution, and biochemical characterization. J. Biol. Chem. 283: 7776-7789, 2008.
K. NADRA, A.S. DE PREUX CHARLES, J.J. MEDARD, W.T. HENDRIKS, G.S. HAN, S. GRES, G.M. CARMAN, J.S. SAULNIER-BLACHE, M.H.G. VERHEIJEN, & R. CHRAST. Phosphatidic acid mediates demyelination in Lpin1 mutant mice. Gene and Development, 15: 1647-1661, 2008.
2007
C. CARPENE, Z. IFFIU-SOLTESZ, S. BOUR, D. PREVOT & P. VALET. Reduction of fat deposition by combined inhibition of monoamine oxidases and semicarbazide-sensitive amine oxidases in obese Zucker rats. Pharmacol. Res. 56: 522-530, 2007.
J.P. PRADERE, S. GRES, J. KLEIN, C. GUIGNE, E. NEAU, P. VALET, D. CALISE, J. CHUN, J.L. BASCANDS, J.S. SAULNIER-BLACHE & J. SCHANSTRA. LPA1 receptor activation promotes renal interstitial fibrosis. J. Am. Soc. Nephrol., 18: 3110-3118, 2007.
S. GARCIA-VICENTE, F. YRAOLA, L. MARTI, E. GONZALEZ-MUNOZ, M.J. GARCIA-BARRADO, C. CANTO, A. ABELLA, S. BOUR, R. ARTUCH, C. SIERRA, N. BRANDI, C. CARPENE, J. MORATINOS, M. CAMPS, M. PALACIN, X. TESTAR, A. GUMA, F. ALBERICIO, M. ROYO, A. MIAN, A.ZORZANO. Oral insulin-mimetic compounds that act independently of insulin. Diabetes. 56: 486-93, 2007.
J.P. PRADERE, E. TARNUS, S. GRES, P. VALET & J.S. SAULNIER-BLACHE. Secretion and lysophospholipase D activity of autotaxin by adipocytes are controled by N-Glycosylation and signal peptidases. Biochem. Biophys. Acta, 1771: 93-102, 2007.
Z. IFFIU-SOLTESZ, D. PREVOT, S. GRES, S. BOUR, E. SZÖKÖ, C. KNAUF, R. BURCELIN, A. FERNANDEZ-QUINTELA, A. LOMBA, F. MILAGRO & C. CARPENE. Influence of benzylamine acute and chronic administrations on glucose tolerance in diabetic and obese mice fed a very high-fat diet. J. Physiol. Biochem., 63: 305-316, 2007.
V. ROLLI, M. RADOSAVLJEVIC, V. ASTIER, C. MACQUIN, I. CASTAN-LAURELL, V. VISENTIN, C. GUIGNE, C. CARPENE, P. VALET, S. GILFILLAN & S. BAHRAM. Lipolysis is altered in MHC class I Zinc-Alpha2-glycoprotein deficient mice. FEBS letters, 581: 394-400, 2007.
S. BOUR, D. DAVIAUD, S. GRES, C. LEFORT, D. PREVOT, A. ZORZANO, M. WABITSCH, J.S. SAULNIER-BLACHE, P. VALET & C. CARPENE. Adipogenesis-related increase of Semicarbazide-Sensitive Amine Oxidase and Monoamine Oxidase in human adipocytes. Biochimie, 89: 916-925, 2007.
P. CLERC, M.G. COLL-CONSTANS, H. LULKA, S. BROUSSAUD, C. GUIGNE, S. LEUNG-THEUNG-LONG, C. PERRIN, C. KNAUF, C. CARPENE, L. PENICAUD, C. SEVA, R. BURCELIN, P. VALET, D. FOURMY &M. DUFRESNE. Involvement of cholecystokinin2 receptor in food intake regulation : hyperphagia and increased fat deposition in cholecystokinin2 receptor-deficient mice. Endocrinology, 148: 1039-1049, 2007.
C. DRAY, D. DAVIAUD, C. GUIGNÉ, P. VALET & I. CASTAN-LAURELL. Caffeine reduces TNF-a up-regulation in human adipose tissue primary culture. J. Physiol. Biochem. 63: 329-336, 2007.
D. PREVOT, S. SOLTESZ, V. ABELLO, E. WANECQ, P. VALET, M. UNZETA & C. CARPENE. Prolonged treatment with aminoguanidine strongly inhibits adipocyte semicarbazide-sensitive amine oxidase and slightly reduces fat deposition in obese Zucker rats. Pharmacol. Res. 56: 70-79, 2007.
J. MINET-RINGUET, P.C. EVEN, P. VALET, C. CARPENE, V. VISENTIN, D. PREVOT, D. DAVIAUD, A. QUIGNARD-BOULANGER, D. TOME & R. DE BEAUREPAIRE. Alteration of lipid metabolism and gene expression in rat adipocytes during chronic olanzapine treatment. Mol. Psychiat. 12: 562-571, 2007.
S. BOUR, D. PREVOT, C. GUIGNE, C. STOLEN, S. JALKANEN, P. VALET & C. CARPENE. Semicarbazide-sensitive amine oxidase substrates fail to induce insulin-like effects in fat cells from AOC3 knockout mice. J. Neural. Trans. 114: 829-833, 2007.
2006
L.A. VAN MEETEREN, P. RUURS, C. STORTELERS, P. BOUWMAN, M.A.VAN ROOIJEN, J.P. PRADERE, T.R. PETTIT, M.J. WAKELAM, J.S. SAULNIER-BLACHE, C.L. MUMMERY, W.H. MOOLENAAR, J. JONKERS. Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development. Mol. Cell. Biol. 26: 5015-22, 2006.
E. WANECQ, S. BOUR, P. WERWAERDE, F. SMIH, P. VALET & C. CARPENE. Increased monoamine oxidase and semicarbazide-sensitive amine oxidase activities in white adipose tissue of obese dogs fed a high fat diet. J. Physiol. Biochem. 62 : 113-124, 2006.
A. GALINIER, A. CARRIERE, Y. FERNANDEZ, C. CARPENE, M. ANDRE, S. CASPAR-BAUGUIL, J.P. THOUVENOT, B. PERIQUET, L. PENICAUD, L. CASTEILLA. Adipose tissue proadipogenic redox changes in obesity. J. Biol. Chem. 281: 12682-7, 2006.
D. DAVIAUD, J. BOUCHER, C. DRAY, C. GUIGNE, S. GESTA, D. QUILLIOT, A. AYAV, O. ZIEGLER, C. CARPENE, J.S. SAULNIER-BLACHE, P. VALET & I. CASTAN-LAURELL. TNFalpha up-regulates apelin expression in human and mouse adipose tissue. FASEB J. 20: 1528-1530, 2006.
C. FERRAND, A. REDONNET, D. PREVOT, C. CARPENE & C. ATGIE. Prolonged treatment with the bêta3-adrenergic agonist CL 316243 induces adipose tissue remodeling in rat but not in guinea pig: 1) fat store depletion and desensitization of bêta3-adrenergic responses. J. Physiol. Biochem., 62: 89-100, 2006.
C. DUFFAUT, S. BOUR, D. PREVOT, L. MARTI, X. TESTAR, A. ZORZANO & C. CARPENE. Prolonged treatment with the bêta3-adrenergic agonist CL 316243 induces adipose tissue remodeling in rat but not in guinea pig: 2) modulation of glucose uptake and monoamine oxidase activity. J. Physiol. Biochem., 62: 101-112, 2006.
S. BOUR, M.C. IGLESIAS-OSMA, L. MARTI, P. DURO, M.J. GARCIA-BARRADO, M.F. PASTOR, D. PREVOT, V. VISENTIN, P. VALET, J. MORATINOS & C. CARPENE. The imidazoline I2-site ligands BU 224 and 2-BFI inhibit MAO-A and MAO-B activities, hydrogen peroxide production, and lipolysis in rodent and human adipocytes. Eur. J. Pharmacol. 552: 20-30, 2006.
C. CHAVEY, J. BOUCHER, M.N. MONTHOUEL-KARTMANN, E.H. SAGE, I. CASTAN-LAURELL, P. VALET, S. TARTARE-DECKERT & E. VAN OBBERGHEN. Regulation of Secreted Protein Acidic and Rich in Cysteine during Adipose Conversion and Adipose Tissue Hyperplasia. Obesity. 14: 1890-1897, 2006.
C. CARPENE, D. DAVIAUD, J. BOUCHER, S. BOUR, V. VISENTIN, S. GRES, C. DUFFAUT, E. FONTANA, X. TESTAR, J.S. SAULNIER-BLACHE & P. VALET. Short- and long-term insulin-like effects of monoamine oxidase and semicarbazide-sensitive amine oxidase substrates in cultured adipocytes. Metabolism. 55: 1397-1405, 2006.
2005
J. MAZEREEUW-HAUTIER, S. GRES, M. FANGUIN, C. CARIVEN, J. FAUVEL, B. PERRET, H. CHAP, J.P. SALLES, J.S. SAULNIER-BLACHE. Production of lysophosphatidic acid in blister fluid: involvement of a lysophospholipase D activity. J. Invest. Dermatol. 125: 421-7, 2005
J. BOUCHER, D. QUILIOT, J.P. PRADERES, M.F. SIMON, S. GRES, C. GUIGNE, D. PREVOT, G. FERRY, J.A. BOUTIN, C. CARPENE, P. VALET & J.S. SAULNIER-BLACHE. Potential involvement of adipocyte insulin-resistance in obesity-associated up-regulation of adipocyte lysophospholipase D / autotaxin expression. Diabetologia, 48: 569–577, 2005.
V. VISENTIN, J. BOUCHER, S. BOUR, D. PREVOT, I. CASTAN, C. CARPENE, & P. VALET. Influence of high-fat feeding on amine oxidase activity in white adipose tissue of mice prone or resistent to diet-induced obesity. J. Physiol. Biochem. 61: 343-352, 2005.
J. BOUCHER, B. MASRI, D. DAVIAUD, S. GESTA, C. GUIGNE, A. MAZZUCOTELLI, I. CASTAN-LAURELL, I. TACK, B. KNIBIEHLER, C. CARPENE, Y. AUDIGIER, J.S. SAULNIER-BLACHE & P. VALET. Apelin, a newly identified adipokine up regulated by insulin and obesity. Endocrinology, 146: 1764-1771, 2005.
S. BOUR, V. VISENTIN, D. PREVOT, D. DAVIAUD, J.S. SAULNIER-BLACHE, C. GUIGNE, P. VALET & C. CARPENE. Effects of oral administration of benzylamine on glucose tolerance and lipid metabolism in rats. J. Physiol. Biochem. 61: 371-380, 2005.
M.F. SIMON, D. DAVIAUD, S. GRES, C. GUIGNE, M. WABITSCH, J. CHUN, P. VALET & J.S. SAULNIER-BLACHE. Lysophosphatidic acid inhibits adipocyte differentiation via LPA1 receptor-dependent down regulation of PPARg2 expression. J. Biol. Chem. 280: 14656-14662, 2005.
C. CARPENE, S. BOUR, V. VISENTIN, F. PELLATI, S. BENVENUTI, M.C. IGLESIAS-OSMA, M.J. GARCIA-BARRADO & P. VALET. Amine oxidase substrates for impaired glucose tolerance correction. J. Physiol. Biochem., 61: 405-420, 2005.
V. VISENTIN, S. BOUR, J. BOUCHER, D. PREVOT, P. VALET, C. ORDENER, A. PARINI & C. CARPENE. Glucose handling in streptozotocin-induced diabetic rats is improved by tyramine but not by the amine oxidase inhibitor semicarbazide. Eur. J. Pharmacol., 522: 139-146, 2005.
M.C. IGLESIAS-OSMA, S. BOUR, M.J. GARCIA-BARRADO, V. VISENTIN, M.F. PASTOR, X. TESTAR, L. MARTI, G. ENRIQUE-TARANCON, P. VALET, J. MORATINOS & C. CARPENE. Methylamine but not mafenide mimics insulin-like activity of the semicarbazide-sensitive amine oxidase-substrate benzylamine on glucose tolerance and on human adipocyte metabolism. Pharmacol. Res. 52: 475-484, 2005.
J. BOUCHER, I. CASTAN-LAURELL, D. DAVIAUD, C. GUIGNE, M. BULEON, C. CARPENE, J.S. SAULNIER-BLACHE & P. VALET. Adipokine expression profile in adipocytes of different mouse models of obesity. Horm. Metab. Res. 37: 761-777, 2005.
2004 (main publications)
A. BOUCHARABA, C.M. SERRE, S. GRES, J.S. SAULNIER-BLACHE, J.C. BORDET, J. GUGLIELMI, P. CLEZARDIN, O. PEYRUCHAUD. Platelet-derived lysophosphatidic acid supports the progression of osteolytic bone metastases in breast cancer. J. Clin. Invest. 114: 1714-25, 2004
V. VISENTIN, D. PREVOT, V. DURAND DE SAINT FRONT, N. MORIN-CUSSAC, C. THALAMAS, J. GALITSKY, P. VALET, A. ZORZANO & C. CARPENE. Alteration of amine oxidase activity in the adipose tissue of obese subjects. Obesity Res., 12: 547-555, 2004.
M.C. IGLESIAS-OSMA, M.J. GARCIA-BARRADO, V. VISENTIN, M.F. PASTOR-MANSILLA, S. BOUR, D. PREVOT, P. VALET, J. MORATINOS & C. CARPENE. Benzylamine exhibits insulin-like effects on glucose disposal, glucose transport and fat cell lipolysis in rabbits and diabetic mice. J. Pharmacol. Exp. Ther., 309: 1-9, 2004.
2003 (main publications)
S. GESTA, K. LOLMEDE, D. DAVIAUD, M. BERLAN, A. BOULOUMIE, M. LAFONTAN, P. VALET & J.S. SAULNIER-BLACHE. Culture of human adipose tissue explants leads to profound alteration of adipocyte gene expression. Horm. Metab. Res., 35: 158-163, 2003.
G. FERRY, E. TELLIER, A. TRY, S. GRES, I. NAIME, M.F. SIMON, M. RODRIGUEZ, J. BOUCHER, I. TACK, S. GESTA, P. CHOMARAT, M. DIEU, M. RAES, J.P. GALIZZI, P. VALET, J. BOUTIN & J.S. SAULNIER-BLACHE. Autotaxin is released from adipocytes, catalyses lysophosphatidic acid synthesis, and activates preadipocyte proliferation: up-regulated expression with adipocyte differentiation and obesity. J. Biol. Chem., 278: 18162-18169, 2003.
2002 (main publications)
S. GESTA, M.F. SIMON, A. REY, D. SIBRAC, A. GIRARD, M. LAFONTAN, P. VALET & J.S. SAULNIER-BLACHE. Secretion of a lysophospholipase D activity by adipocytes : involvement in lysophosphatidic acid synthesis. J. Lipid Res., 43: 904-910,2002.
M.F. SIMON, A. REY, I. CASTAN-LAURELL, S. GRES, D. SIBRAC, P. VALET & J.S. SAULNIER-BLACHE. Expression of ecto-lipid phosphate phosphohydrolases in 3T3F442A preadipocytes and adipocytes : involvement in the control of lysophosphatidic acid production. J. Biol. Chem., 277: 23131-23136, 2002.
N. MORIN, V. VISENTIN, D. CALISE, L. MARTI, A. ZORZANO, X. TESTAR, P. VALET, Y. FISCHER & C. CARPENE. Tyramine stimulates glucose uptake in insuline-sensitive tissues in vitro and in vivo via its oxidation by amine oxidases. J. Pharmacol. Exp. Ther., 303: 1238-1247, 2002.
J. BOUCHER, I. CASTAN-LAURELL, S. LE-LAY, D. GRUJIC, D. SIBRAC, S. KRIEF, M. LAFONTAN, B. LOWELL, I. DUGAIL, J.S. SAULNIER-BLACHE & P. VALET. Human alpha2A-adrenergic receptor gene expressed in transgenic mice adipose tissue under the control of its regulatory elements. J. Mol. Endocrinol., 29: 251-264, 2002.
2001 (main publications)
N. AL-MAKDISSY, A. BIANCHI, M. YOUNSI, E. PICARD, P. VALET, N. MARTINET, M. DAUCA & M. DONNER. Down regulation of peroxisome proliferator-activated receptor g gene expression by sphingomyelins. Febs letters, 493 : 75-79, 2001.
C. PAGES, D. Daviaud, S. an, s. krief, M. lafontan, P. Valet & j.S. Saulnier-blache. Endothelial Differentiation Gene-2 receptor is involved in lysophosphatidic acid-dependent control of 3T3F442A preadipocyte proliferation and spreading. J. Biol. Chem., 276 : 11599-11605,2001.
V. VISENTIN, N. MORIN, E. FONTANA, D. PREVOT, J. BOUCHER, I. CASTAN, P. VALET, D. GRUJIC & C. CARPENE. Dual action of octopamine on glucose transport into adipocytes : inhibition via beta3-adrenoceptor activation and stimulation via oxidation by amine oxidases. J. Pharmacol. Exp. Ther., 299 : 96-104, 2001.
S. LE LAY, J. BOUCHER, A. REY, I. CASTAN-LAURELL, S. KRIEF, P. FERRE, P. VALET & I. DUGAIL. Decreased resistin expression in mice with different sensitivities to high-fat diet. Biochem. Biophys. Res. Com., 289 : 564-567, 2001.
S. GESTA, J. HEJNOVA, M. BERLAN, D. DAVIAUD, F. CRAMPES, V. STICH, P. VALET & J.S. SAULNIER-BLACHE. In vitro and in vivo impairment of alpha2-adrenergic receptor-dependent antilipolysis by fatty acids in human adipose tissue. Horm. Metab. Res., 33 : 701-707, 2001.
2000 (main publications)
P. VALET, D. GRUJIC, J. WADE, M. ITO, M.C. ZINGARETTI, V. SOLOVEVA, S. R. ROSS, R.A. GRAVES, S. CINTI, M. LAFONTAN & B.B. LOWELL.Expression of human a2-adrenergic receptors in adipose tissue of b3-adrenergic receptor deficient mice promotes diet-induced obesity. J. Biol. Chem., 275 : 34797-34802, 2000.
j.S. SAULNIER-BLACHE, A. GIRARD, M.F. SIMON, M. LAFONTAN & P. VALET. A Simple and Highly Sensitive Radioenzymatic Assay for Lysophosphatidic acid Quantification. J. Lipid Res., 41 : 1947-1951, 2000.
1999 (main publications)
C. PAGES, P. VALET, O. JEANNETON, A. ZAKAROFF-GIRARD, P. BARBE, M. RECORD, C. WOLF, F. CHEVY, M. LAFONTAN & J.S. SAULNIER-BLACHE. Alpha2-adrenergic receptor-mediated release of lysophosphatidic acid by adipocytes: a paracrine signal for preadipocyte growth. Lipids 34: S79, 1999.
C. PAGES, A. REY, M. LAFONTAN, P. VALET & j.S. SAULNIER-BLACHE. Ca++-independent phospholipase A2 (iPLA2) is required for alpha2-adrenergic-induced preadipocyte spreading. Biochem. Biophys. Res. Com. 265 : 572-576, 1999.
1998 (main publications)
P. VALET, C. PAGES, O. JEANNETON, D. DAVIAUD, P. BARBE, M. RECORD, j.S. SAULNIER-BLACHE & M. LAFONTAN. Alpha2-adrenergic receptor-mediated release of lysophosphatidic by adipocytes: a paracrine signal for preadipocyte growth.J. Clin. Invest. 101: 1431-1438, 1998.
S. BETUING, D. DAVIAUD, C. PAGES, E. BONNARD, P. VALET, M. LAFONTAN & J.S. SAULNIER-BLACHE. Gbg-independent coupling of alpha2-adrenergic receptor to p21rhoA in preadipocytes. J. Biol. Chem. 273: 15804-15810, 1998.
